BAIT
ATG16L1
1500009K01Rik, Apg16l, Atg16l, WDR30
autophagy related 16-like 1 (S. cerevisiae)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TFAM
AI661103, Hmgts, mtTFA, tsHMG
transcription factor A, mitochondrial
GO Process (7)
GO Function (8)
GO Component (4)
Gene Ontology Biological Process
- chromatin remodeling [IBA]
- mitochondrial respiratory chain complex assembly [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of transcription, DNA-templated [IBA, TAS]
- transcription from mitochondrial promoter [ISO]
- transcription initiation from mitochondrial promoter [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- DNA binding, bending [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- chromatin binding [IBA, ISO]
- heat shock protein binding [ISO]
- mitochondrial light strand promoter sense binding [ISO]
- poly(A) RNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO, TAS]
- DNA binding [ISO]
- DNA binding, bending [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- chromatin binding [IBA, ISO]
- heat shock protein binding [ISO]
- mitochondrial light strand promoter sense binding [ISO]
- poly(A) RNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO, TAS]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID