BAIT
ATG16L1
1500009K01Rik, Apg16l, Atg16l, WDR30
autophagy related 16-like 1 (S. cerevisiae)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TOP2A
Top-2, RP23-333D2.5
topoisomerase (DNA) II alpha
GO Process (18)
GO Function (19)
GO Component (8)
Gene Ontology Biological Process
- ATP catabolic process [IGI, ISO]
- DNA ligation [ISO]
- DNA topological change [IDA, ISO]
- DNA unwinding involved in DNA replication [IBA]
- apoptotic chromosome condensation [IBA, ISO]
- cellular response to DNA damage stimulus [ISO]
- chromosome condensation [IMP]
- chromosome segregation [IDA, IMP, ISO]
- embryonic cleavage [IMP]
- hematopoietic progenitor cell differentiation [IMP]
- mitotic DNA integrity checkpoint [IBA]
- mitotic recombination [IBA]
- positive regulation of apoptotic process [ISO]
- positive regulation of single stranded viral RNA replication via double stranded DNA intermediate [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of viral genome replication [ISO]
- resolution of meiotic recombination intermediates [IBA]
- sister chromatid segregation [IBA]
Gene Ontology Molecular Function- ATP binding [ISO]
- DNA binding [ISO]
- DNA binding, bending [ISO]
- DNA topoisomerase activity [ISO]
- DNA topoisomerase type II (ATP-hydrolyzing) activity [IDA, IGI, ISO]
- DNA-dependent ATPase activity [ISO]
- chromatin binding [ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- magnesium ion binding [ISO]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase C binding [ISO]
- sequence-specific DNA binding [ISO]
- structure-specific DNA binding [ISO]
- ubiquitin binding [ISO]
- ATP binding [ISO]
- DNA binding [ISO]
- DNA binding, bending [ISO]
- DNA topoisomerase activity [ISO]
- DNA topoisomerase type II (ATP-hydrolyzing) activity [IDA, IGI, ISO]
- DNA-dependent ATPase activity [ISO]
- chromatin binding [ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- magnesium ion binding [ISO]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase C binding [ISO]
- sequence-specific DNA binding [ISO]
- structure-specific DNA binding [ISO]
- ubiquitin binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID