BAIT
ATG16L1
1500009K01Rik, Apg16l, Atg16l, WDR30
autophagy related 16-like 1 (S. cerevisiae)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
WASF2
AW742646, D4Ertd13e, WAVE2, RP23-341B14.1
WAS protein family, member 2
GO Process (12)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- Rac protein signal transduction [IMP]
- actin cytoskeleton organization [IMP]
- actin filament-based movement [IMP]
- ameboidal-type cell migration [IMP]
- angiogenesis [IMP]
- cellular component movement [IMP]
- endocytosis [IDA]
- lamellipodium assembly [IMP]
- lamellipodium morphogenesis [IMP]
- megakaryocyte development [IMP]
- negative regulation of stress fiber assembly [ISO]
- positive regulation of lamellipodium assembly [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID