An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

ATG5 is required for B cell polarization and presentation of particulate antigens.

Arbogast F, Arnold J, Hammann P, Kuhn L, Chicher J, Murera D, Weishaar J, Muller S, Fauny JD, Gros F

The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]

Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary

ATG16L1

Gene Ontology Biological Process

Gene Ontology Molecular Function

identical protein binding [ISO]protein binding [IPI]

Gene Ontology Cellular Component

RAE1