BAIT
ATG16L1
1500009K01Rik, Apg16l, Atg16l, WDR30
autophagy related 16-like 1 (S. cerevisiae)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MED4
2410046H15Rik, DRIP36, HSPC126, TRAP36, Vdirp, Vdrip
mediator complex subunit 4
GO Process (6)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- androgen receptor signaling pathway [ISO]
- intracellular steroid hormone receptor signaling pathway [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- transcription from RNA polymerase II promoter [ISO]
- transcription initiation from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- mediator complex [IDA, ISA, ISO]
- membrane [ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID