BAIT
ATG16L1
1500009K01Rik, Apg16l, Atg16l, WDR30
autophagy related 16-like 1 (S. cerevisiae)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ZC3HAV1
1200014N16Rik, 2900058M19Rik, 9130009D18Rik, 9830115L13Rik, ARTD13, D6Bwg1452e, ZAP
zinc finger CCCH type, antiviral 1
GO Process (12)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- cellular response to exogenous dsRNA [IDA]
- negative regulation of viral genome replication [ISO]
- positive regulation of ATPase activity [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of RIG-I signaling pathway [ISO, TAS]
- positive regulation of interferon-alpha production [ISO]
- positive regulation of interferon-beta production [ISO]
- positive regulation of mRNA catabolic process [ISO]
- positive regulation of type I interferon production [IDA]
- regulation of defense response to virus by host [ISO]
- response to virus [ISO]
- suppression by virus of host molecular function [IMP]
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID