BAIT
ATG16L1
1500009K01Rik, Apg16l, Atg16l, WDR30
autophagy related 16-like 1 (S. cerevisiae)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DOCK2
AI662014, AW122239, CED-5, Hch, MBC, RP23-32J15.2
dedicator of cyto-kinesis 2
GO Process (16)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- T cell activation [IMP]
- T cell proliferation [IMP]
- alpha-beta T cell activation [IMP]
- alpha-beta T cell proliferation [IMP]
- chemotaxis [IMP]
- cytoskeleton organization [IDA]
- establishment of T cell polarity [IMP]
- immunological synapse formation [IMP]
- macropinocytosis [IMP]
- membrane raft polarization [IMP]
- myeloid dendritic cell activation involved in immune response [IMP]
- negative thymic T cell selection [IMP]
- positive regulation of Rac GTPase activity [IMP]
- positive regulation of Rac protein signal transduction [IC]
- positive regulation of phagocytosis [IMP]
- positive thymic T cell selection [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID