BAIT
ATG16L1
APG16L, ATG16A, ATG16L, IBD10, WDR30, hCG_1817841
autophagy related 16-like 1 (S. cerevisiae)
GO Process (3)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ALYREF
ALY, ALY/REF, BEF, REF, THOC4
Aly/REF export factor
GO Process (12)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
- RNA splicing [TAS]
- gene expression [TAS]
- mRNA 3'-end processing [TAS]
- mRNA export from nucleus [IMP, TAS]
- mRNA splicing, via spliceosome [IC, TAS]
- osteoblast differentiation [IDA]
- positive regulation of DNA-templated transcription, elongation [IMP]
- regulation of DNA recombination [IMP]
- replication fork processing [IMP]
- termination of RNA polymerase II transcription [TAS]
- transcription from RNA polymerase II promoter [TAS]
- viral mRNA export from host cell nucleus [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID