BAIT
ATG16L1
1500009K01Rik, Apg16l, Atg16l, WDR30
autophagy related 16-like 1 (S. cerevisiae)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PICALM
CALM, CLTH, PAP180, fit-1, fit1, mKIAA4114
phosphatidylinositol binding clathrin assembly protein
GO Process (22)
GO Function (6)
GO Component (18)
Gene Ontology Biological Process
- axonogenesis [IMP, ISO]
- cargo loading into vesicle [ISO]
- cell proliferation [ISO]
- clathrin coat assembly [ISO]
- clathrin-mediated endocytosis [ISO]
- dendrite morphogenesis [IMP, ISO]
- endosomal transport [ISO]
- hemopoiesis [IMP]
- iron ion homeostasis [ISO]
- iron ion import into cell [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of receptor-mediated endocytosis [ISO]
- positive regulation of beta-amyloid formation [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- receptor internalization [ISO]
- receptor-mediated endocytosis [IDA, ISO]
- regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [ISO]
- regulation of endocytosis [ISO]
- regulation of protein localization [ISO]
- regulation of protein transport [ISO]
- vesicle-mediated transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- AP-2 adaptor complex [ISO]
- clathrin coat of coated pit [ISO]
- clathrin-coated vesicle [ISO]
- coated pit [IDA, ISO]
- endosome [ISO]
- intracellular [IDA]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- neurofibrillary tangle [ISO]
- neuronal cell body [ISO]
- neuronal postsynaptic density [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [ISO]
- postsynaptic membrane [ISO]
- presynaptic membrane [ISO]
- synapse [ISO]
- synaptic vesicle [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID