BAIT
ATG16L1
1500009K01Rik, Apg16l, Atg16l, WDR30
autophagy related 16-like 1 (S. cerevisiae)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PRDX2
AL022839, Band-8, NkefB, PRP, PrxII, TDX1, TPx, TPx-B, TR, TSA, Tdpx1, Torin
peroxiredoxin 2
GO Process (22)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- T cell proliferation [IMP]
- activation of MAPK activity [IMP]
- cellular response to oxidative stress [ISO]
- homeostasis of number of cells [IMP]
- hydrogen peroxide catabolic process [IMP]
- hydrogen peroxide metabolic process [IMP]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of T cell differentiation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- negative regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of reactive oxygen species metabolic process [IMP]
- oxidation-reduction process [ISS]
- positive regulation of blood coagulation [IMP]
- regulation of apoptotic process [ISO]
- regulation of hydrogen peroxide metabolic process [IMP]
- removal of superoxide radicals [IMP, ISO]
- respiratory burst involved in inflammatory response [IMP]
- response to lipopolysaccharide [IMP]
- response to oxidative stress [ISO, TAS]
- thymus development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID