BAIT
ATG16L1
1500009K01Rik, Apg16l, Atg16l, WDR30
autophagy related 16-like 1 (S. cerevisiae)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PLEK
2010300B13Rik, RP23-348N2.1
pleckstrin
GO Process (20)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- cell projection organization [ISO]
- cortical actin cytoskeleton organization [ISO]
- integrin-mediated signaling pathway [ISO]
- negative regulation of G-protein coupled receptor protein signaling pathway [ISO]
- negative regulation of inositol phosphate biosynthetic process [ISO]
- phosphatidylinositol metabolic process [ISO]
- phospholipase C-inhibiting G-protein coupled receptor signaling pathway [ISO]
- platelet aggregation [IMP, ISO]
- positive regulation of actin filament bundle assembly [ISO]
- positive regulation of actin filament depolymerization [IMP, ISO]
- positive regulation of inositol-polyphosphate 5-phosphatase activity [ISO]
- positive regulation of integrin activation [IMP]
- positive regulation of platelet activation [IMP]
- protein kinase C signaling [IMP]
- protein secretion by platelet [IMP]
- regulation of cell diameter [ISO]
- ruffle organization [ISO]
- thrombin receptor signaling pathway [IMP, ISO]
- vesicle docking involved in exocytosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID