BAIT
ATG16L1
1500009K01Rik, Apg16l, Atg16l, WDR30
autophagy related 16-like 1 (S. cerevisiae)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
STK4
AI447339, AU020804, Kas-2, Mst1, Ysk3, RP23-346D16.3
serine/threonine kinase 4
GO Process (24)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- apoptotic process [ISO]
- cell differentiation involved in embryonic placenta development [IGI]
- cell morphogenesis [ISO]
- central nervous system development [IGI]
- endocardium development [IGI]
- hepatocyte apoptotic process [IGI]
- hippo signaling [IGI, IMP, ISO]
- intracellular signal transduction [IBA, ISO]
- keratinocyte differentiation [IGI]
- negative regulation of canonical Wnt signaling pathway [IGI, ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of organ growth [IGI]
- neural tube formation [IGI]
- patterning of blood vessels [IGI]
- peptidyl-serine phosphorylation [ISO]
- positive regulation of apoptotic process [IGI, ISO]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [IGI]
- positive regulation of fat cell differentiation [ISO]
- positive regulation of protein binding [ISO]
- primitive hemopoiesis [IGI]
- protein autophosphorylation [ISO]
- protein phosphorylation [IBA, ISO]
- response to stress [IBA]
- signal transduction by phosphorylation [IBA]
Gene Ontology Molecular Function- ATP binding [ISO]
- identical protein binding [ISO]
- magnesium ion binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activity [ISO]
- receptor signaling protein serine/threonine kinase activity [IBA]
- transcription factor binding [ISO]
- ATP binding [ISO]
- identical protein binding [ISO]
- magnesium ion binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activity [ISO]
- receptor signaling protein serine/threonine kinase activity [IBA]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- cytoplasm [IDA, ISO]
- intracellular [IGI]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ATG5 is required for B cell polarization and presentation of particulate antigens.
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing. Moreover, antigen presentation to ... [more]
Autophagy Feb. 01, 2019; 15(2);280-294 [Pubmed: 30196744]
Throughput
- High Throughput
Curated By
- BioGRID