An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

Hu WF, Krieger KL, Lagundzin D, Li X, Cheung RS, Taniguchi T, Johnson KR, Bessho T, Monteiro ANA, Woods NT

BRCA1 C-terminal domains are found in a specialized group of 23 proteins that function in the DNA damage response to protect genomic integrity. C-terminal domain phosphatase 1 (CTDP1) is the only phosphatase with a BRCA1 C-terminal domain in the human proteome, yet direct participation in the DNA damage response has not been reported. Examination of the CTDP1 BRCA1 C-terminal domain-specific ... [more]

Cell Death Discov Jun. 27, 2019; 5();105 [Pubmed: 31240132]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary

CTDP1

Gene Ontology Biological Process

Gene Ontology Molecular Function

CTD phosphatase activity [IDA]DNA-directed RNA polymerase activity [TAS]

Gene Ontology Cellular Component

CDIPT