BAIT

PSMA3

HC8, PSC3
proteasome (prosome, macropain) subunit, alpha type, 3
Homo sapiens
PREY

SH3GLB2

PP6569, PP9455, RRIG1, RP11-167N5.3
SH3-domain GRB2-like endophilin B2
GO Process (0)
GO Function (1)
GO Component (3)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Combined treatment of human multiple myeloma cells with bortezomib and doxorubicin alters the interactome of 20S proteasomes.

Mittenberg AG, Kuzyk VO, Shabelnikov SV, Gorbach DP, Shatrova AN, Fedorova OA, Barlev NA

The proteasome is the key player in targeted degradation of cellular proteins and serves as a therapeutic target for treating several blood malignancies. Although in general, degradation of proteins via the proteasome requires their ubiquitination, a subset of proteins can be degraded independently of their ubiquitination by direct interaction with subunits of the 20S proteasome core. Thus, investigation of the ... [more]

Cell Cycle Jul. 17, 2018; 17(14);1745-1756 [Pubmed: 30009671]

Throughput

  • High Throughput

Curated By

  • BioGRID