ACTC1
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- actin filament-based movement [IDA]
- actin-myosin filament sliding [IMP]
- actomyosin structure organization [ISS]
- apoptotic process [ISS]
- cardiac muscle tissue morphogenesis [ISS]
- cardiac myofibril assembly [ISS]
- heart contraction [IMP]
- muscle filament sliding [TAS]
- skeletal muscle thin filament assembly [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
WASL
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- actin polymerization or depolymerization [TAS]
- axon guidance [TAS]
- cellular component movement [TAS]
- innate immune response [TAS]
- membrane budding [ISS]
- negative regulation of membrane tubulation [IDA]
- nitric oxide metabolic process [TAS]
- positive regulation of clathrin-mediated endocytosis [ISS]
- positive regulation of filopodium assembly [ISS]
- protein complex assembly [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- small molecule metabolic process [TAS]
- vesicle organization [ISS]
- vesicle transport along actin filament [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.
In addition to its essential functions within the cytoskeleton, actin also localizes to the cell nucleus, where it is linked to many important nuclear processes from gene expression to maintenance of genomic integrity. However, the molecular mechanisms by which actin operates in the nucleus remain poorly understood. Here, we have used two complementary mass spectrometry (MS) techniques, AP-MS and BioID, ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ACTC1 WASL | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID