BAIT
SFPQ
POMP100, PPP1R140, PSF
splicing factor proline/glutamine-rich
GO Process (9)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- RNA splicing [TAS]
- alternative mRNA splicing, via spliceosome [IMP]
- histone H3 deacetylation [ISS]
- mRNA processing [TAS]
- negative regulation of circadian rhythm [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IDA]
- regulation of circadian rhythm [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RAD51D
BROVCA4, R51H3, RAD51L3, TRAD
RAD51 paralog D
GO Process (6)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
The splicing-factor related protein SFPQ/PSF interacts with RAD51D and is necessary for homology-directed repair and sister chromatid cohesion.
DNA double-stranded breaks (DSBs) are among the most severe forms of DNA damage and responsible for chromosomal translocations that may lead to gene fusions. The RAD51 family plays an integral role in preserving genome stability by homology directed repair of DSBs. From a proteomics screen, we recently identified SFPQ/PSF as an interacting partner with the RAD51 paralogs, RAD51D, RAD51C and ... [more]
Nucleic Acids Res. Jan. 01, 2011; 39(1);132-45 [Pubmed: 20813759]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAD51D SFPQ | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| SFPQ RAD51D | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID