BAIT

DJR-1.1

CELE_B0432.2, B0432.2
djr-1.1 encodes a glyoxylase orthologous to human DJ-1 (OMIM:602533, mutated in early-onset Parkinson disease); DJR-1.1 is required for resistance to rotenone, a mitochondrial complex I inhibitor that mimics Parkinson disease (PD); djr-1.1(RNAi) animals are partly rescued from PD-like sensitivity by D-beta-hydroxybutyrate or tauroursodeoxycholic acid, and fully rescued by both; by orthology with DJ-1, DJR-1.1 may promote stability of the transcription factors SKN-1 or SKNR-1 (homologs of mammalian NFE2L2); DJR-1.1 is expressed primarily in the intestine and localizes to the nucleus and the cytoplasm.
Caenorhabditis elegans
PREY

F53F4.10

CELE_F53F4.10
F53F4.10 is orthologous to the human gene NADH-ubiquinone oxidoreductase flavoprotein 2 (NDUFV2; complex I of the respiratory chain); F53F4.10 protein is predicted to be mitochondrial.
GO Process (0)
GO Function (0)
GO Component (0)
Caenorhabditis elegans

Co-fractionation

Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.

Publication

EPIC: software toolkit for elution profile-based inference of protein complexes.

Hu LZ, Goebels F, Tan JH, Wolf E, Kuzmanov U, Wan C, Phanse S, Xu C, Schertzberg M, Fraser AG, Bader GD, Emili A

Protein complexes are key macromolecular machines of the cell, but their description remains incomplete. We and others previously reported an experimental strategy for global characterization of native protein assemblies based on chromatographic fractionation of biological extracts coupled to precision mass spectrometry analysis (chromatographic fractionation-mass spectrometry, CF-MS), but the resulting data are challenging to process and interpret. Here, we describe EPIC ... [more]

Nat. Methods Jul. 15, 2019; (); [Pubmed: 31308550]

Quantitative Score

  • 0.708 [Confidence Score]

Throughput

  • High Throughput

Additional Notes

  • High confidence protein interactions have an EPIC PPI score >= 0.5

Curated By

  • BioGRID