BAX
Gene Ontology Biological Process
- B cell apoptotic process [IDA]
- B cell receptor apoptotic signaling pathway [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA, IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [IDA]
- apoptotic mitochondrial changes [IDA]
- apoptotic process [NAS, TAS]
- apoptotic signaling pathway [IDA]
- endoplasmic reticulum calcium ion homeostasis [TAS]
- establishment or maintenance of transmembrane electrochemical gradient [IDA]
- extrinsic apoptotic signaling pathway [IDA]
- extrinsic apoptotic signaling pathway in absence of ligand [IBA]
- extrinsic apoptotic signaling pathway via death domain receptors [IC]
- intrinsic apoptotic signaling pathway [IDA, TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IBA]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IMP]
- mitochondrial fragmentation involved in apoptotic process [IDA]
- mitochondrial fusion [IDA]
- negative regulation of protein binding [IDA]
- positive regulation of apoptotic DNA fragmentation [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of endoplasmic reticulum unfolded protein response [IMP]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [TAS]
- positive regulation of neuron apoptotic process [IDA]
- positive regulation of protein oligomerization [IDA]
- positive regulation of release of cytochrome c from mitochondria [IDA]
- protein homooligomerization [IDA]
- protein oligomerization [IDA]
- regulation of mitochondrial membrane potential [IDA]
- regulation of protein heterodimerization activity [IPI]
- regulation of protein homodimerization activity [IDA]
- release of cytochrome c from mitochondria [IDA]
- release of matrix enzymes from mitochondria [IDA]
- response to toxic substance [IDA]
- retinal cell apoptotic process [IMP]
- transformed cell apoptotic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- BAX complex [IDA]
- Bcl-2 family protein complex [IDA]
- cytosol [IDA, TAS]
- endoplasmic reticulum [IDA]
- endoplasmic reticulum membrane [IDA]
- extracellular vesicular exosome [IDA]
- membrane [IDA]
- mitochondrial outer membrane [IBA, TAS]
- mitochondrial permeability transition pore complex [IDA]
- mitochondrion [IDA]
- nuclear envelope [IDA]
- nucleus [IDA, IMP]
- pore complex [IDA]
OYE2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
Old yellow enzymes, highly homologous FMN oxidoreductases with modulating roles in oxidative stress and programmed cell death in yeast.
In a genetic screen to identify modifiers of Bax-dependent lethality in yeast, the C terminus of OYE2 was isolated based on its capacity to restore sensitivity to a Bax-resistant yeast mutant strain. Overexpression of full-length OYE2 suppresses Bax lethality in yeast, lowers endogenous reactive oxygen species (ROS), increases resistance to H(2)O(2)-induced programmed cell death (PCD), and significantly lowers ROS levels ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: mitochondrial morphology (APO:0000055)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BAX OYE2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 257928 | |
| BAX OYE2 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 458015 |
Curated By
- BioGRID