BAIT

RAD52

recombinase RAD52, L000001572, YML032C
Protein that stimulates strand exchange; stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis and UV induced sister chromatid recombination
Saccharomyces cerevisiae (S288c)
PREY

ULP1

NIB1, SUMO protease ULP1, S000029323, L000001249, YPL020C
Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions
GO Process (2)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes.

Palancade B, Liu X, Garcia-Rubio M, Aguilera A, Zhao X, Doye V

Increasing evidences suggest that nuclear pore complexes (NPCs) control different aspects of nuclear metabolism, including transcription, nuclear organization, and DNA repair. We previously established that the Nup84 complex, a major NPC building block, is part of a genetic network involved in DNA repair. Here, we show that double-strand break (DSB) appearance is linked to a shared function of the Nup84 ... [more]

Mol. Biol. Cell Aug. 01, 2007; 18(8);2912-23 [Pubmed: 17538013]

Throughput

  • Low Throughput

Ontology Terms

  • heat sensitivity (APO:0000147)
  • viability (APO:0000111)

Additional Notes

  • Overexpression of ULP1 rescues a rad52 nup133 or a rad52 nup60 double mutant.
  • genetic complex
  • partial rescue Overexpression of ULP1 rescues a rad52 nup133 or a rad52 nup60 double mutant.

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
ULP1 RAD52
Synthetic Growth Defect
Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

High-BioGRID
258043
ULP1 RAD52
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
162778

Curated By

  • BioGRID