CYE-1
Gene Ontology Biological Process
- DNA endoreduplication [IMP]
- G1/S transition of mitotic cell cycle [IDA, IMP]
- body morphogenesis [IMP]
- embryo development ending in birth or egg hatching [IMP]
- germ cell development [IMP]
- germline cell cycle switching, mitotic to meiotic cell cycle [IGI, IMP]
- hermaphrodite genitalia development [IMP]
- mitotic cell cycle arrest [IGI]
- nematode larval development [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of vulval development [IMP]
- post-embryonic development [IMP]
- posttranscriptional regulation of gene expression [IGI, IMP]
- protein phosphorylation [IMP]
- regulation of mitosis [IDA]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SMA-6
Gene Ontology Biological Process
- BMP signaling pathway [ISS]
- body morphogenesis [IMP]
- dauer larval development [IGI]
- defense response to fungus [IMP]
- innate immune response [IMP]
- maintenance of protein location in nucleus [IMP]
- nematode male tail tip morphogenesis [IGI, IMP]
- positive regulation of multicellular organism growth [IGI, IMP]
- positive regulation of protein catabolic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of cell adhesion [IMP]
- regulation of cell morphogenesis [IMP]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
EPIC: software toolkit for elution profile-based inference of protein complexes.
Protein complexes are key macromolecular machines of the cell, but their description remains incomplete. We and others previously reported an experimental strategy for global characterization of native protein assemblies based on chromatographic fractionation of biological extracts coupled to precision mass spectrometry analysis (chromatographic fractionation-mass spectrometry, CF-MS), but the resulting data are challenging to process and interpret. Here, we describe EPIC ... [more]
Quantitative Score
- 0.527 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- High confidence protein interactions have an EPIC PPI score >= 0.5
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SMA-6 CYE-1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | 4.7 | BioGRID | 466203 |
Curated By
- BioGRID