BAIT
C31C9.2
CELE_C31C9.2
C31C9.2 is orthologous to the human gene PHOSPHOGLYCERATE DEHYDROGENASE (PHGDH; OMIM:606879), which when mutated leads to phosphoglycerate dehydrogenase deficiency.
GO Process (0)
GO Function (0)
GO Component (0)
Caenorhabditis elegans
PREY
SOD-1
CELE_C15F1.7
Protein SOD-1
GO Process (11)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- age-dependent response to oxidative stress [IDA]
- determination of adult lifespan [IMP]
- germ cell development [IMP]
- negative regulation of vulval development [IMP]
- oviposition [IMP]
- oxidation-reduction process [IDA]
- regulation of brood size [IMP]
- regulation of vulval development [IGI]
- removal of superoxide radicals [IMP]
- striated muscle myosin thick filament assembly [IMP]
- superoxide metabolic process [IDA]
Gene Ontology Molecular Function
Caenorhabditis elegans
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
EPIC: software toolkit for elution profile-based inference of protein complexes.
Protein complexes are key macromolecular machines of the cell, but their description remains incomplete. We and others previously reported an experimental strategy for global characterization of native protein assemblies based on chromatographic fractionation of biological extracts coupled to precision mass spectrometry analysis (chromatographic fractionation-mass spectrometry, CF-MS), but the resulting data are challenging to process and interpret. Here, we describe EPIC ... [more]
Nat. Methods Jul. 15, 2019; (); [Pubmed: 31308550]
Quantitative Score
- 0.535 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- High confidence protein interactions have an EPIC PPI score >= 0.5
Curated By
- BioGRID