APOH
Gene Ontology Biological Process
- blood coagulation, intrinsic pathway [IDA]
- negative regulation of angiogenesis [IDA]
- negative regulation of blood coagulation [IDA]
- negative regulation of endothelial cell migration [IDA]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of fibrinolysis [IDA]
- negative regulation of myeloid cell apoptotic process [IDA]
- negative regulation of smooth muscle cell apoptotic process [IDA]
- plasminogen activation [IDA]
- positive regulation of blood coagulation [TAS]
- positive regulation of lipoprotein lipase activity [IDA]
- regulation of fibrinolysis [IDA]
- triglyceride metabolic process [IDA]
- triglyceride transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
LRP8
Gene Ontology Biological Process
- ammon gyrus development [ISS]
- blood coagulation [TAS]
- cytokine-mediated signaling pathway [NAS]
- endocytosis [IDA]
- lipid metabolic process [NAS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- phototransduction, visible light [TAS]
- positive regulation of CREB transcription factor activity [ISS]
- positive regulation of dendrite development [ISS]
- positive regulation of dendritic spine morphogenesis [ISS]
- positive regulation of peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of protein tyrosine kinase activity [ISS]
- proteolysis [NAS]
- receptor-mediated endocytosis [IDA]
- reelin-mediated signaling pathway [ISS]
- regulation of synaptic transmission [ISS]
- retinoid metabolic process [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'.
Patients with prolonged clotting times caused by lupus anticoagulant (LAC) are at risk for thrombosis. This paradoxal association is not understood. LAC is frequently caused by anti-beta2-glycoprotein I (beta 2GPI) antibodies. Antibody-induced dimerization of beta 2GPI increases the affinity of beta 2GPI for phospholipids, explaining the observed prolonged clotting times. We constructed dimers of beta 2GPI that mimic effects of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID