BAIT
RNF216
CAHH, TRIAD3, U7I1, UBCE7IP1, ZIN
ring finger protein 216
GO Process (4)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
TLR5
MELIOS, SLE1, SLEB1, TIL3, RP11-239E10.1
toll-like receptor 5
GO Process (8)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- cellular response to mechanical stimulus [IEP]
- innate immune response [TAS]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of toll-like receptor signaling pathway [IDA]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors.
Activation of Toll-like receptors (TLRs) results in a proinflammatory response needed to combat infection. Thus, limiting TLR signaling is essential for preventing a protective response from causing injury to the host. Here we describe how a RING finger protein, Triad3A, acts as an E3 ubiquitin-protein ligase and enhances ubiquitination and proteolytic degradation of some TLRs. Triad3A overexpression promoted substantial degradation ... [more]
Nat. Immunol. May. 01, 2004; 5(5);495-502 [Pubmed: 15107846]
Throughput
- Low Throughput
Curated By
- BioGRID