ADCY6
Gene Ontology Biological Process
- activation of phospholipase C activity [TAS]
- activation of protein kinase A activity [TAS]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [TAS]
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [TAS]
- cAMP biosynthetic process [IDA]
- cellular response to catecholamine stimulus [IDA]
- cellular response to glucagon stimulus [TAS]
- cellular response to prostaglandin E stimulus [IDA]
- dopamine receptor signaling pathway [IDA]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of neuron projection development [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- synaptic transmission [TAS]
- transmembrane transport [TAS]
- water transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CHRNA7
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- calcium ion transport [IDA, IMP]
- cation transmembrane transport [IDA]
- cellular calcium ion homeostasis [IMP]
- cognition [IMP, NAS]
- ion transmembrane transport [IDA]
- ion transport [NAS]
- memory [NAS]
- negative regulation of tumor necrosis factor production [IDA, IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell proliferation [IMP]
- response to hypoxia [IDA]
- response to nicotine [IDA]
- signal transduction [IDA]
- synaptic transmission [TAS]
Gene Ontology Molecular Function- acetylcholine binding [IDA]
- acetylcholine receptor activity [IDA]
- acetylcholine-activated cation-selective channel activity [IDA]
- acetylcholine-gated cation channel activity [IDA]
- beta-amyloid binding [IPI]
- chloride channel regulator activity [IDA]
- protein homodimerization activity [IDA]
- toxic substance binding [IDA]
- acetylcholine binding [IDA]
- acetylcholine receptor activity [IDA]
- acetylcholine-activated cation-selective channel activity [IDA]
- acetylcholine-gated cation channel activity [IDA]
- beta-amyloid binding [IPI]
- chloride channel regulator activity [IDA]
- protein homodimerization activity [IDA]
- toxic substance binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Nicotinic acetylcholine receptor alpha 7 regulates cAMP signal within lipid rafts.
Neuronal nicotinic acetylcholine receptors (nAChRs) are made of multiple subunits with diversified functions. The nAChR alpha 7-subunit has a property of high Ca2+ permeability and may have specific functions and localization within the plasma membrane as a signal transduction molecule. In PC-12 cells, fractionation by sucrose gradient centrifugation revealed that nAChR alpha 7 existed in low-density, cholesterol-enriched plasma membrane microdomains ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID