BAIT

KCNJ3

GIRK1, KGA, KIR3.1
potassium inwardly-rectifying channel, subfamily J, member 3
GO Process (4)
GO Function (2)
GO Component (2)
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K+ channel.

Ivanina T, Rishal I, Varon D, Mullner C, Frohnwieser-Steinecke B, Schreibmayer W, Dessauer CW, Dascal N

G protein-activated K+ channels (Kir3 or GIRK) are activated by direct binding of Gbetagamma. The binding sites of Gbetagamma in the ubiquitous GIRK1 (Kir3.1) subunit have not been unequivocally charted, and in the neuronal GIRK2 (Kir3.2) subunit the binding of Gbetagamma has not been studied. We verified and extended the map of Gbetagamma-binding sites in GIRK1 by using two approaches: ... [more]

J. Biol. Chem. Aug. 01, 2003; 278(31);29174-83 [Pubmed: 12743112]

Throughput

  • Low Throughput

Curated By

  • BioGRID