BAIT
KLP-19
CELE_Y43F4B.6, Y43F4B.6
klp-19 encodes a plus-end-directed microtubule motor protein that is most closely related to motors of the kinesin-4 family; KLP-19 activity is essential for embryonic and larval development and is required for generating a force that aligns sister chromatid kinetochores directly opposite the spindle poles thus ensuring proper holocentric chromosome segregation; KLP-19 expression is detected in embryos and in the gonad, where it is most strongly expressed in distal mitotic nuclei and in late meiotic prophase nucleoplasm; during meiosis and mitosis, KLP-19 expression is dynamic and is detected in the nucleoplasm, the spindle body, in association with condensed chromosomes (particularly between homologous chromosomes), and in the spindle interzone.
GO Process (10)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- ATP catabolic process [IBA]
- embryo development ending in birth or egg hatching [IMP]
- hermaphrodite genitalia development [IMP]
- metabolic process [IBA]
- microtubule-based movement [IBA]
- mitotic nuclear division [IMP]
- mitotic spindle organization [IMP]
- nematode larval development [IMP]
- receptor-mediated endocytosis [IMP]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Caenorhabditis elegans
PREY
CLEC-80
CELE_Y54G2A.39
Protein CLEC-80
GO Process (0)
GO Function (0)
GO Component (0)
Caenorhabditis elegans
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
EPIC: software toolkit for elution profile-based inference of protein complexes.
Protein complexes are key macromolecular machines of the cell, but their description remains incomplete. We and others previously reported an experimental strategy for global characterization of native protein assemblies based on chromatographic fractionation of biological extracts coupled to precision mass spectrometry analysis (chromatographic fractionation-mass spectrometry, CF-MS), but the resulting data are challenging to process and interpret. Here, we describe EPIC ... [more]
Nat. Methods Jul. 15, 2019; (); [Pubmed: 31308550]
Quantitative Score
- 0.537 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- High confidence protein interactions have an EPIC PPI score >= 0.5
Curated By
- BioGRID