BAIT

ZBTB7A

FBI-1, FBI1, LRF, ZBTB7, ZNF857A, pokemon
zinc finger and BTB domain containing 7A
UPS Project
GO Process (1)
GO Function (2)
GO Component (0)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Homo sapiens
PREY

CCT4

CCT-DELTA, Cctd, SRB
chaperonin containing TCP1, subunit 4 (delta)
GO Process (3)
GO Function (2)
GO Component (6)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.

Liu XS, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs RM, Rajendran A, Xie A, Shah JV, Davis AJ, Scully R, Lunardi A, Pandolfi PP

Leukemia/lymphoma-related factor (LRF) is a POZ/BTB and Krueppel (POK) transcriptional repressor characterized by context-dependent key roles in cell fate decision and tumorigenesis. Here we demonstrate an unexpected transcription-independent function for LRF in the classical non-homologous end joining (cNHEJ) pathway of double-strand break (DSB) repair. We find that LRF loss in cell lines and mouse tissues results in defective cNHEJ, genomic ... [more]

Nat Commun Oct. 08, 2015; 6();8325 [Pubmed: 26446488]

Throughput

  • High Throughput

Curated By

  • BioGRID