BAIT
ZBTB7A
FBI-1, FBI1, LRF, ZBTB7, ZNF857A, pokemon
zinc finger and BTB domain containing 7A
GO Process (1)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
EIF4A3
DDX48, MUK34, NMP265, NUK34, RCPS, eIF4AIII
eukaryotic translation initiation factor 4A3
GO Process (12)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- RNA metabolic process [TAS]
- cytokine-mediated signaling pathway [TAS]
- embryonic cranial skeleton morphogenesis [IMP]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- mRNA splicing, via spliceosome [IC]
- negative regulation of translation [IDA]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [IMP, TAS]
- nuclear-transcribed mRNA poly(A) tail shortening [TAS]
- positive regulation of translation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.
Leukemia/lymphoma-related factor (LRF) is a POZ/BTB and Krueppel (POK) transcriptional repressor characterized by context-dependent key roles in cell fate decision and tumorigenesis. Here we demonstrate an unexpected transcription-independent function for LRF in the classical non-homologous end joining (cNHEJ) pathway of double-strand break (DSB) repair. We find that LRF loss in cell lines and mouse tissues results in defective cNHEJ, genomic ... [more]
Nat Commun Oct. 08, 2015; 6();8325 [Pubmed: 26446488]
Throughput
- High Throughput
Curated By
- BioGRID