BAIT

FH

HLRCC, LRCC, MCL, MCUL1
fumarate hydratase
GO Process (3)
GO Function (1)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

HIST1H2AH

H2A/S, H2AFALii, H2AH, dJ86C11.1
histone cluster 1, H2ah
GO Process (0)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation.

Jiang Y, Qian X, Shen J, Wang Y, Li X, Liu R, Xia Y, Chen Q, Peng G, Lin SY, Lu Z

Histone methylation regulates DNA repair. However, the mechanisms that underlie the regulation of histone methylation during this repair remain to be further defined. Here, we show that exposure to ionizing radiation induces DNA-PK-dependent phosphorylation of nuclear fumarase at Thr 236, which leads to an interaction between fumarase and the histone variant H2A.Z at DNA double-strand break (DSB) regions. Locally generated fumarate ... [more]

Nat. Cell Biol. Sep. 01, 2015; 17(9);1158-68 [Pubmed: 26237645]

Throughput

  • High Throughput

Curated By

  • BioGRID