BAIT
APP
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
amyloid beta (A4) precursor protein
GO Process (29)
GO Function (8)
GO Component (21)
Gene Ontology Biological Process
- adult locomotory behavior [ISS]
- axon cargo transport [ISS]
- axon midline choice point recognition [ISS]
- axonogenesis [ISS]
- blood coagulation [TAS]
- cellular copper ion homeostasis [ISS]
- collateral sprouting in absence of injury [ISS]
- dendrite development [ISS]
- endocytosis [ISS]
- extracellular matrix organization [ISS, TAS]
- innate immune response [TAS]
- ionotropic glutamate receptor signaling pathway [ISS]
- locomotory behavior [ISS]
- mRNA polyadenylation [ISS]
- mating behavior [ISS]
- negative regulation of endopeptidase activity [IDA]
- neuron apoptotic process [IMP]
- neuron projection development [ISS]
- neuron remodeling [ISS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of mitotic cell cycle [ISS]
- protein phosphorylation [ISS]
- regulation of epidermal growth factor-activated receptor activity [ISS]
- regulation of multicellular organism growth [ISS]
- regulation of synapse structure or activity [ISS]
- regulation of translation [ISS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISS]
- axon [ISS]
- cell surface [IDA]
- cytoplasm [IDA, ISS]
- cytosol [TAS]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- endosome [IDA]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of membrane [ISS]
- integral component of plasma membrane [TAS]
- intracellular membrane-bounded organelle [IDA]
- membrane raft [IDA]
- nuclear envelope lumen [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- platelet alpha granule lumen [TAS]
- receptor complex [IDA]
- synapse [IDA]
Homo sapiens
PREY
KIAA0319
DYLX2, DYX2, NMIG
KIAA0319
GO Process (2)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein.
Alzheimer's disease (AD) is a neurodegenerative disorder in which amyloid β plaques are a pathological characteristic. Little is known about the physiological functions of amyloid β precursor protein (APP). Based on its structure as a type I transmembrane protein, it has been proposed that APP might be a receptor, but so far, no ligand has been reported. In the present ... [more]
Neurosci Bull Apr. 01, 2016; 32(2);171-6 [Pubmed: 26960425]
Throughput
- High Throughput
Curated By
- BioGRID