CD2
Gene Ontology Biological Process
- T cell activation [TAS]
- apoptotic process [TAS]
- blood coagulation [TAS]
- cell surface receptor signaling pathway [TAS]
- heterotypic cell-cell adhesion [IDA]
- leukocyte migration [TAS]
- membrane raft polarization [TAS]
- natural killer cell activation [NAS]
- positive regulation of interferon-gamma secretion [IDA]
- positive regulation of interleukin-8 secretion [IMP]
- positive regulation of myeloid dendritic cell activation [NAS]
- positive regulation of tumor necrosis factor production [IDA]
- regulation of T cell differentiation [NAS]
- single organismal cell-cell adhesion [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SH3KBP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85.
Recruitment of CD2 to the immunological synapse in response to antigen is dependent on its proline-rich cytoplasmic tail. A peptide from this region (CD2:322-339) isolated CMS (human CD2AP); a related protein, CIN85; and the actin capping protein, CAPZ from a T cell line. In BIAcore analyses, the N-terminal SH3 domains of CMS and CIN85 bound CD2:322-339 with similar dissociation constants ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SH3KBP1 CD2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CD2 SH3KBP1 | Co-crystal Structure Co-crystal Structure Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex. | Low | - | BioGRID | 1240420 | |
| SH3KBP1 CD2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| CD2 SH3KBP1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| CD2 SH3KBP1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID