VHL
Gene Ontology Biological Process
- cell morphogenesis [NAS]
- cellular response to hypoxia [TAS]
- negative regulation of apoptotic process [NAS]
- negative regulation of cell proliferation [TAS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [IDA]
- positive regulation of cell differentiation [NAS]
- positive regulation of transcription, DNA-templated [IMP]
- protein stabilization [NAS]
- protein ubiquitination [IDA, IMP]
- proteolysis [TAS]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- regulation of transcription, DNA-templated [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TRIM28
Gene Ontology Biological Process
- DNA repair [IDA]
- epithelial to mesenchymal transition [ISS]
- gene expression [TAS]
- innate immune response [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of viral release from host cell [IDA]
- positive regulation of DNA repair [IDA]
- positive regulation of transcription factor import into nucleus [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- protein oligomerization [IDA]
- protein sumoylation [IDA]
- protein ubiquitination [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- Krueppel-associated box domain binding [IDA]
- chromo shadow domain binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [ISS]
- transcription corepressor activity [IDA]
- ubiquitin protein ligase binding [IDA]
- ubiquitin-protein transferase activity [IDA]
- zinc ion binding [IDA]
- DNA binding [IDA]
- Krueppel-associated box domain binding [IDA]
- chromo shadow domain binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [ISS]
- transcription corepressor activity [IDA]
- ubiquitin protein ligase binding [IDA]
- ubiquitin-protein transferase activity [IDA]
- zinc ion binding [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity.
The von Hippel-Lindau tumor suppressor (pVHL) is a component of an E3 ubiquitin ligase and targets hypoxia-inducible factor-1alpha (HIF-1alpha) for ubiquitylation and degradation under normoxic conditions. pVHL also directly inhibits HIF-1alpha transactivation by recruiting histone deacetylases. Here, we report a novel pVHL-interacting protein that functions as a negative regulator of HIF-1alpha transactivation. This protein, generated from the ZnF197 locus by ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID