Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Promoter nucleosome dynamics regulated by signalling through the CTD code.

Materne P, Anandhakumar J, Migeot V, Soriano I, Yague-Sanz C, Hidalgo E, Mignion C, Quintales L, Antequera F, Hermand D

The phosphorylation of the RNA polymerase II C-terminal domain (CTD) plays a key role in delineating transcribed regions within chromatin by recruiting histone methylases and deacetylases. Using genome-wide nucleosome mapping, we show that CTD S2 phosphorylation controls nucleosome dynamics in the promoter of a subset of 324 genes, including the regulators of cell differentiation ste11 and metabolic adaptation inv1. Mechanistic ... [more]

Elife Jun. 23, 2015; 4(0);e09008 [Pubmed: 26098123]

Throughput

  • High Throughput

Ontology Terms

  • phenotype: viability (APO:0000111)

Additional Notes

  • SGA

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
LSK1 HIP1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-3.4744BioGRID
524939

Curated By

  • BioGRID