A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Promoter nucleosome dynamics regulated by signalling through the CTD code.

Materne P, Anandhakumar J, Migeot V, Soriano I, Yague-Sanz C, Hidalgo E, Mignion C, Quintales L, Antequera F, Hermand D

The phosphorylation of the RNA polymerase II C-terminal domain (CTD) plays a key role in delineating transcribed regions within chromatin by recruiting histone methylases and deacetylases. Using genome-wide nucleosome mapping, we show that CTD S2 phosphorylation controls nucleosome dynamics in the promoter of a subset of 324 genes, including the regulators of cell differentiation ste11 and metabolic adaptation inv1. Mechanistic ... [more]

Elife Jun. 23, 2015; 4(0);e09008 [Pubmed: 26098123]

Throughput

Low Throughput

Ontology Terms

phenotype: mating efficiency (APO:0000034)

Additional Notes

deletion of set1 suppressed the sterility of the lsk1 mutant

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
LSK1 SET1	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Roguev A (2008)	High	-4.3698	BioGRID	527067

Curated By

BioGRID

Interaction Summary

LSK1

Gene Ontology Biological Process

Gene Ontology Molecular Function

cyclin binding [IPI]cyclin-dependent protein kinase activity [IDA]

Gene Ontology Cellular Component

SET1