PREY

PSMA1

HC2, HEL-S-275, NU, PROS30
proteasome (prosome, macropain) subunit, alpha type, 1
GO Process (21)
GO Function (2)
GO Component (8)
Homo sapiens

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

mTOR Modulates Methamphetamine-Induced Toxicity through Cell Clearing Systems.

Lazzeri G, Biagioni F, Fulceri F, Busceti CL, Scavuzzo MC, Ippolito C, Salvetti A, Lenzi P, Fornai F

Methamphetamine (METH) is abused worldwide, and it represents a threat for public health. METH exposure induces a variety of detrimental effects. In fact, METH produces a number of oxidative species, which lead to lipid peroxidation, protein misfolding, and nuclear damage. Cell clearing pathways such as ubiquitin-proteasome (UP) and autophagy (ATG) are involved in METH-induced oxidative damage. Although these pathways were ... [more]

Oxid Med Cell Longev Jan. 17, 2019; 2018();6124745 [Pubmed: 30647813]

Throughput

  • Low Throughput

Curated By

  • BioGRID