BAIT
TGFBR2
AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGFR-2, TGFbeta-RII
transforming growth factor, beta receptor II (70/80kDa)
GO Process (27)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- activation of protein kinase activity [ISS]
- apoptotic process [IDA]
- blood vessel development [TAS]
- brain development [ISS]
- embryonic cranial skeleton morphogenesis [ISS]
- embryonic hemopoiesis [ISS]
- heart development [ISS]
- myeloid dendritic cell differentiation [ISS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- palate development [ISS]
- pathway-restricted SMAD protein phosphorylation [IDA]
- patterning of blood vessels [ISS]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of B cell tolerance induction [ISS]
- positive regulation of NK T cell differentiation [ISS]
- positive regulation of T cell tolerance induction [ISS]
- positive regulation of cell proliferation [TAS]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of tolerance induction to self antigen [ISS]
- protein phosphorylation [IDA]
- regulation of cell proliferation [ISS]
- response to cholesterol [IDA]
- response to drug [IDA]
- transforming growth factor beta receptor signaling pathway [IC, IDA, IMP, TAS]
- vasculogenesis [ISS]
Gene Ontology Molecular Function- SMAD binding [IDA]
- glycosaminoglycan binding [IDA]
- protein binding [IPI]
- transforming growth factor beta binding [IDA, IPI]
- transforming growth factor beta-activated receptor activity [IC, IDA, IMP]
- transmembrane receptor protein serine/threonine kinase activity [IDA]
- type I transforming growth factor beta receptor binding [IDA, IPI]
- type III transforming growth factor beta receptor binding [IDA]
- SMAD binding [IDA]
- glycosaminoglycan binding [IDA]
- protein binding [IPI]
- transforming growth factor beta binding [IDA, IPI]
- transforming growth factor beta-activated receptor activity [IC, IDA, IMP]
- transmembrane receptor protein serine/threonine kinase activity [IDA]
- type I transforming growth factor beta receptor binding [IDA, IPI]
- type III transforming growth factor beta receptor binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
STAT1
CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
signal transducer and activator of transcription 1, 91kDa
GO Process (32)
GO Function (10)
GO Component (8)
Gene Ontology Biological Process
- JAK-STAT cascade [IDA]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- apoptotic process [ISS]
- blood circulation [ISS]
- cellular response to interferon-beta [IMP]
- cytokine-mediated signaling pathway [TAS]
- endothelial cell migration [IMP]
- interferon-gamma-mediated signaling pathway [IDA, ISS, TAS]
- metanephric mesenchymal cell differentiation [ISS]
- metanephric mesenchymal cell proliferation involved in metanephros development [ISS]
- negative regulation by virus of viral protein levels in host cell [IMP]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- negative regulation of angiogenesis [IMP]
- negative regulation of endothelial cell proliferation [IMP]
- negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [ISS]
- negative regulation of metanephric nephron tubule epithelial cell differentiation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of smooth muscle cell proliferation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of apoptotic process [TAS]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of type I interferon-mediated signaling pathway [TAS]
- renal tubule development [IMP]
- response to cAMP [ISS]
- response to cytokine [ISS]
- response to peptide hormone [ISS]
- transcription from RNA polymerase II promoter [IDA]
- tumor necrosis factor-mediated signaling pathway [IDA]
- type I interferon signaling pathway [ISS, TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IDA]
- double-stranded DNA binding [IDA]
- enzyme binding [IPI]
- identical protein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- tumor necrosis factor receptor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IDA]
- double-stranded DNA binding [IDA]
- enzyme binding [IPI]
- identical protein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- tumor necrosis factor receptor binding [IPI]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis.
TGF-β is pro-metastatic for the late-stage breast cancer cells. Despite recent progress, the regulation of TGF-β type II receptor remains uncertain. Here we report that FAF1 destabilizes TβRII on the cell surface by recruiting the VCP/E3 ligase complex, thereby limiting excessive TGF-β response. Importantly, activated AKT directly phosphorylates FAF1 at Ser 582, which disrupts the FAF1-VCP complex and reduces FAF1 ... [more]
Nat Commun Dec. 26, 2016; 8();15021 [Pubmed: 28443643]
Throughput
- High Throughput
Curated By
- BioGRID