BAIT
FAF1
HFAF1s, UBXD12, UBXN3A, hFAF1, CGI-03
Fas (TNFRSF6) associated factor 1
GO Process (7)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- cell death [IMP]
- cytoplasmic sequestering of NF-kappaB [IMP]
- positive regulation of apoptotic process [NAS]
- positive regulation of protein complex assembly [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [NAS]
- regulation of protein catabolic process [IMP]
- regulation of protein kinase activity [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RPSA
37LRP, 67LR, ICAS, LAMBR, LAMR1, LBP, LBP/p40, LRP, LRP/LR, NEM/1CHD4, SA, lamR, p40
ribosomal protein SA
GO Process (17)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IBA]
- endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IBA]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- rRNA export from nucleus [IBA]
- ribosomal small subunit assembly [IBA]
- translation [IBA, IC, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis.
TGF-β is pro-metastatic for the late-stage breast cancer cells. Despite recent progress, the regulation of TGF-β type II receptor remains uncertain. Here we report that FAF1 destabilizes TβRII on the cell surface by recruiting the VCP/E3 ligase complex, thereby limiting excessive TGF-β response. Importantly, activated AKT directly phosphorylates FAF1 at Ser 582, which disrupts the FAF1-VCP complex and reduces FAF1 ... [more]
Nat Commun Dec. 26, 2016; 8();15021 [Pubmed: 28443643]
Throughput
- High Throughput
Curated By
- BioGRID