BAIT
PRKD2
PKD2, nPKC-D2, HSPC187
protein kinase D2
GO Process (31)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- T cell receptor signaling pathway [IDA]
- cell death [IMP]
- cellular response to vascular endothelial growth factor stimulus [IGI, IMP]
- endothelial tube morphogenesis [TAS]
- intracellular signal transduction [IMP]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of CREB transcription factor activity [IGI]
- positive regulation of DNA biosynthetic process [ISS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of T cell receptor signaling pathway [ISS]
- positive regulation of angiogenesis [IGI, IMP]
- positive regulation of blood vessel endothelial cell migration [IGI, IMP]
- positive regulation of cell adhesion [IMP]
- positive regulation of endothelial cell chemotaxis [IMP]
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [IGI, IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IGI, IMP]
- positive regulation of fibroblast growth factor receptor signaling pathway [IMP]
- positive regulation of histone deacetylase activity [IGI]
- positive regulation of interleukin-2 production [ISS]
- positive regulation of interleukin-8 production [IMP]
- positive regulation of intracellular signal transduction [IMP]
- positive regulation of peptidyl-serine phosphorylation [IGI]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IMP]
- protein autophosphorylation [IDA, TAS]
- protein kinase D signaling [IGI]
- protein phosphorylation [NAS]
- vascular endothelial growth factor receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
FXR1
FXR1P
fragile X mental retardation, autosomal homolog 1
GO Process (2)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.
Protein Kinase D (PKD) family contains PKD1, PKD2, and PKD3 in human. Compared to consistent tumor-suppressive functions of PKD1 in breast cancer, how PKD2/3 functions in breast cancer are not fully understood. In the current study, we found that PKD2 and PKD3 but not PKD1 were preferentially overexpressed in breast cancer and involved in regulating cell proliferation and metastasis. Integrated ... [more]
Cancer Med Feb. 01, 2019; 8(2);729-741 [Pubmed: 30652415]
Throughput
- High Throughput
Curated By
- BioGRID