BAIT
H2AFX
H2A.X, H2A/X, H2AX
H2A histone family, member X
GO Process (8)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EHMT2
BAT8, C6orf30, G9A, GAT8, KMT1C, NG36, DAAP-66K18.3
euchromatic histone-lysine N-methyltransferase 2
GO Process (6)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.
Chromatin connects DNA damage response factors to sites of damaged DNA to promote the signaling and repair of DNA lesions. The histone H2A variants H2AX, H2AZ, and macroH2A represent key chromatin constituents that facilitate DNA repair. Through proteomic screening of these variants, we identified ZMYM3 (zinc finger, myeloproliferative, and mental retardation-type 3) as a chromatin-interacting protein that promotes DNA repair ... [more]
Genes Dev. Dec. 01, 2016; 31(3);260-274 [Pubmed: 28242625]
Throughput
- High Throughput
Curated By
- BioGRID