BAIT
H2AFY
H2A.y, H2A/y, H2AF12M, H2AFJ, MACROH2A1.1, mH2A1, macroH2A1.2
H2A histone family, member Y
GO Process (11)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- dosage compensation [IDA]
- establishment of protein localization to chromatin [IMP]
- negative regulation of cell cycle G2/M phase transition [IMP]
- negative regulation of gene expression, epigenetic [IMP]
- negative regulation of histone phosphorylation [IMP]
- negative regulation of protein serine/threonine kinase activity [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter [IGI, IMP]
- nucleosome assembly [NAS]
- regulation of cell growth [IGI]
- regulation of chromatin silencing at rDNA [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ADNP2
ZNF508
ADNP homeobox 2
GO Process (5)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.
Chromatin connects DNA damage response factors to sites of damaged DNA to promote the signaling and repair of DNA lesions. The histone H2A variants H2AX, H2AZ, and macroH2A represent key chromatin constituents that facilitate DNA repair. Through proteomic screening of these variants, we identified ZMYM3 (zinc finger, myeloproliferative, and mental retardation-type 3) as a chromatin-interacting protein that promotes DNA repair ... [more]
Genes Dev. Dec. 01, 2016; 31(3);260-274 [Pubmed: 28242625]
Throughput
- High Throughput
Curated By
- BioGRID