CSNK2B
Gene Ontology Biological Process
- adiponectin-activated signaling pathway [IDA]
- axon guidance [TAS]
- cellular protein complex assembly [NAS]
- endothelial tube morphogenesis [IMP]
- mitotic cell cycle [TAS]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cell proliferation [TAS]
- positive regulation of activin receptor signaling pathway [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- protein phosphorylation [TAS]
- regulation of DNA binding [NAS]
- regulation of protein kinase activity [NAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CRY2
Gene Ontology Biological Process
- blue light signaling pathway [NAS]
- circadian regulation of gene expression [ISS]
- circadian rhythm [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- glucose homeostasis [ISS]
- negative regulation of circadian rhythm [ISS]
- negative regulation of glucocorticoid receptor signaling pathway [ISS]
- negative regulation of phosphoprotein phosphatase activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, ISS]
- photoreactive repair [IDA]
- regulation of circadian rhythm [ISS]
- regulation of sodium-dependent phosphate transport [IDA]
Gene Ontology Molecular Function- DNA (6-4) photolyase activity [IDA]
- DNA binding [IDA]
- FAD binding [ISS]
- blue light photoreceptor activity [NAS]
- damaged DNA binding [IDA]
- deoxyribodipyrimidine photo-lyase activity [IDA]
- phosphatase binding [IPI]
- protein binding [IPI]
- single-stranded DNA binding [IDA]
- transcription factor binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [ISS]
- ubiquitin binding [IDA]
- DNA (6-4) photolyase activity [IDA]
- DNA binding [IDA]
- FAD binding [ISS]
- blue light photoreceptor activity [NAS]
- damaged DNA binding [IDA]
- deoxyribodipyrimidine photo-lyase activity [IDA]
- phosphatase binding [IPI]
- protein binding [IPI]
- single-stranded DNA binding [IDA]
- transcription factor binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [ISS]
- ubiquitin binding [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock.
Intracellular circadian clocks, composed of clock genes that act in transcription-translation feedback loops, drive global rhythmic expression of the mammalian transcriptome and allow an organism to anticipate to the momentum of the day. Using a novel clock-perturbing peptide, we established a pivotal role for casein kinase (CK)-2-mediated circadian BMAL1-Ser90 phosphorylation (BMAL1-P) in regulating central and peripheral core clocks. Subsequent analysis ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CSNK2B CRY2 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID