BAIT
MAD2L2
MAD2B, POLZ2, REV7, RP3-330O12.4
MAD2 mitotic arrest deficient-like 2 (yeast)
GO Process (17)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- DNA damage response, signal transduction resulting in transcription [IDA]
- DNA repair [TAS]
- actin filament organization [IMP]
- double-strand break repair [IGI]
- mitotic spindle assembly checkpoint [TAS]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of cell-cell adhesion mediated by cadherin [IMP]
- negative regulation of epithelial to mesenchymal transition [IMP]
- negative regulation of mitotic anaphase-promoting complex activity [IDA]
- negative regulation of protein catabolic process [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription by competitive promoter binding [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription regulatory region DNA binding [IMP]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of cell growth [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ESYT2
CHR2SYT, E-Syt2, FAM62B, tcag7.562
extended synaptotagmin-like protein 2
GO Process (0)
GO Function (7)
GO Component (5)
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The shieldin complex mediates 53BP1-dependent DNA repair.
53BP1 is a chromatin-binding protein that regulates the repair of DNA double-strand breaks by suppressing the nucleolytic resection of DNA termini1,2. This function of 53BP1 requires interactions with PTIP3 and RIF14-9, the latter of which recruits REV7 (also known as MAD2L2) to break sites10,11. How 53BP1-pathway proteins shield DNA ends is currently unknown, but there are two models that provide the ... [more]
Nature Dec. 01, 2017; 560(7716);117-121 [Pubmed: 30022168]
Throughput
- Low Throughput
Curated By
- BioGRID