BAIT
PPK-2
CELE_Y48G9A.8, Y48G9A.8
ppk-2 encodes a Type II phosphatidylinositol-4-phosphate kinase (PIP4K) that is one of three C. elegans PIP kinase homologs; PPK-2 is predicted to catalyze the phosphorylation of phosphatidylinositol-5-phosphate (PIP) on the 4-OH position to generate PI(4,5)P2; a deletion allele of ppk-2 is viable and does not affect PIP2 levels, suggesting that PPK-2 is not essential for PIP2 production.
GO Process (0)
GO Function (0)
GO Component (0)
Caenorhabditis elegans
PREY
K09D9.12
CELE_K09D9.12
Protein K09D9.12
GO Process (0)
GO Function (0)
GO Component (0)
Caenorhabditis elegans
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
EPIC: software toolkit for elution profile-based inference of protein complexes.
Protein complexes are key macromolecular machines of the cell, but their description remains incomplete. We and others previously reported an experimental strategy for global characterization of native protein assemblies based on chromatographic fractionation of biological extracts coupled to precision mass spectrometry analysis (chromatographic fractionation-mass spectrometry, CF-MS), but the resulting data are challenging to process and interpret. Here, we describe EPIC ... [more]
Nat. Methods Jul. 15, 2019; (); [Pubmed: 31308550]
Quantitative Score
- 0.508 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- High confidence protein interactions have an EPIC PPI score >= 0.5
Curated By
- BioGRID