PEX5
Gene Ontology Biological Process
- negative regulation of protein homotetramerization [IDA]
- protein import into peroxisome matrix [IGI, IMP, NAS]
- protein import into peroxisome matrix, docking [IDA]
- protein import into peroxisome matrix, translocation [IDA]
- protein import into peroxisome membrane [IMP]
- protein targeting to peroxisome [IDA, IMP]
- protein tetramerization [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ACOT8
Gene Ontology Biological Process
- acyl-CoA metabolic process [IDA]
- alpha-linolenic acid metabolic process [TAS]
- bile acid biosynthetic process [TAS]
- bile acid metabolic process [TAS]
- cellular lipid metabolic process [TAS]
- dicarboxylic acid catabolic process [IDA]
- fatty acid beta-oxidation using acyl-CoA oxidase [TAS]
- peroxisome fission [IDA]
- small molecule metabolic process [TAS]
- unsaturated fatty acid metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- peroxisomal matrix [IDA, IMP, TAS]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of Peroxisomal Protein Complexes with PTS Receptors, Pex5 and Pex7, in Mammalian Cells.
Pex5 and Pex7 are cytosolic receptors for peroxisome targeting signal type-1 (PTS1) and type-2 (PTS2), respectively, and play a pivotal role in import of peroxisomal matrix proteins. Recent advance in mass spectrometry analysis has facilitated comprehensive analysis of protein-protein interaction network by a combination with immunoprecipitation or biochemical purification. In this chapter, we introduce several findings obtained by these methods ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PEX5 ACOT8 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 828764 | |
| PEX5 ACOT8 | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | High | - | BioGRID | - | |
| PEX5 ACOT8 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID