BAIT
ZC3H7A
ZC3H7, ZC3HDC7, HSPC055
zinc finger CCCH-type containing 7A
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
TLN1
ILWEQ, TLN, RP11-112J3.1
talin 1
GO Process (12)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell-cell junction assembly [TAS]
- cellular component movement [NAS]
- cellular protein metabolic process [TAS]
- cytoskeletal anchoring at plasma membrane [NAS]
- endoplasmic reticulum unfolded protein response [TAS]
- muscle contraction [TAS]
- platelet activation [TAS]
- platelet aggregation [IMP]
- platelet degranulation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.
Glioblastoma therapies have remained elusive due to limitations in understanding mechanisms of growth and survival of the tumorigenic population. Using CRISPR-Cas9 approaches in patient-derived GBM stem cells (GSCs) to interrogate function of the coding genome, we identify actionable pathways responsible for growth, which reveal the gene-essential circuitry of GBM stemness and proliferation. In particular, we characterize members of the SOX ... [more]
Cell Rep Apr. 16, 2019; 27(3);971-986.e9 [Pubmed: 30995489]
Throughput
- High Throughput
Curated By
- BioGRID