BAIT
ATG9A
AU019532, Apg9l1, Atg9, Atg9l1
autophagy related 9A
GO Process (8)
GO Function (0)
GO Component (10)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Mus musculus
PREY
EEA1
A430109M19Rik, B230358H09Rik, ZFYVE2
early endosome antigen 1
GO Process (2)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting.
Mutations in a number of genes cause familial forms of Parkinson's disease (PD), including mutations in the vacuolar protein sorting 35 ortholog (VPS35) and parkin genes. In this study, we identify a novel functional interaction between parkin and VPS35. We demonstrate that parkin interacts with and robustly ubiquitinates VPS35 in human neural cells. Familial parkin mutations are impaired in their ... [more]
Hum. Mol. Genet. Dec. 15, 2017; 27(18);3189-3205 [Pubmed: 29893854]
Throughput
- Low Throughput
Curated By
- BioGRID