BAIT
SORT1
2900053A11Rik, AI852375, Ntr3, Ntsr3, RP23-27B23.3
sortilin 1
GO Process (16)
GO Function (5)
GO Component (13)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- Golgi to endosome transport [ISO]
- endocytosis [ISO]
- endosome to lysosome transport [ISO]
- endosome transport via multivesicular body sorting pathway [ISO]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- glucose import [IMP, ISO]
- myotube differentiation [IMP, ISO]
- negative regulation of lipoprotein lipase activity [ISO]
- nerve growth factor signaling pathway [ISO]
- neuropeptide signaling pathway [ISO]
- neurotrophin TRK receptor signaling pathway [ISO]
- plasma membrane to endosome transport [ISO]
- regulation of gene expression [ISO]
- response to insulin [IMP, ISO]
- vesicle organization [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- cell surface [ISO]
- clathrin-coated vesicle [ISO]
- coated pit [ISO]
- cytoplasmic membrane-bounded vesicle [ISO]
- dendrite [ISO]
- early endosome [ISO]
- integral component of membrane [ISO]
- intracellular membrane-bounded organelle [ISO]
- neuronal cell body [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- trans-Golgi network transport vesicle [IDA]
Mus musculus
PREY
EEA1
A430109M19Rik, B230358H09Rik, ZFYVE2
early endosome antigen 1
GO Process (2)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting.
Mutations in a number of genes cause familial forms of Parkinson's disease (PD), including mutations in the vacuolar protein sorting 35 ortholog (VPS35) and parkin genes. In this study, we identify a novel functional interaction between parkin and VPS35. We demonstrate that parkin interacts with and robustly ubiquitinates VPS35 in human neural cells. Familial parkin mutations are impaired in their ... [more]
Hum. Mol. Genet. Dec. 15, 2017; 27(18);3189-3205 [Pubmed: 29893854]
Throughput
- Low Throughput
Curated By
- BioGRID