Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

Distinct 'safe zones' at the nuclear envelope ensure robust replication of heterochromatic chromosome regions.

Ebrahimi H, Masuda H, Jain D, Cooper JP

Chromosome replication and transcription occur within a complex nuclear milieu whose functional subdomains are beginning to be mapped out. Here we delineate distinct domains of the fission yeast nuclear envelope (NE), focusing on regions enriched for the inner NE protein, Bqt4, or the lamin interacting domain protein, Lem2. Bqt4 is relatively mobile around the NE and acts in two capacities. ... [more]

Elife Dec. 03, 2017; 7(); [Pubmed: 29722648]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: vegetative growth (APO:0000106)

Additional Notes

  • Figure 8

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
DCR1 BQT4
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-3.0439BioGRID
762590

Curated By

  • BioGRID