BAIT
FLCN
BHD, FLCL
folliculin
GO Process (28)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- TOR signaling [IMP]
- cell-cell junction assembly [ISS]
- hemopoiesis [ISS]
- in utero embryonic development [ISS]
- negative regulation of ATP biosynthetic process [ISS]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of Rho protein signal transduction [IMP]
- negative regulation of TOR signaling [ISS]
- negative regulation of cell growth [IDA]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation involved in kidney development [ISS]
- negative regulation of energy homeostasis [ISS]
- negative regulation of gene expression [ISS]
- negative regulation of mitochondrion organization [ISS]
- negative regulation of protein kinase B signaling [ISS]
- negative regulation of protein localization to nucleus [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of TOR signaling [ISS]
- positive regulation of apoptotic process [ISS]
- positive regulation of cell adhesion [IMP]
- positive regulation of protein phosphorylation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA, ISS]
- regulation of TOR signaling [ISS]
- regulation of cytokinesis [IMP]
- regulation of histone acetylation [ISS]
- regulation of pro-B cell differentiation [ISS]
- regulation of protein phosphorylation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RAB10
RAB10, member RAS oncogene family
GO Process (21)
GO Function (4)
GO Component (14)
Gene Ontology Biological Process
- GTP catabolic process [IBA]
- Golgi to plasma membrane protein transport [ISS]
- Golgi to plasma membrane transport [ISS]
- Rab protein signal transduction [IBA]
- antigen processing and presentation [IMP]
- axonogenesis [ISS]
- basolateral protein localization [ISS]
- cellular response to insulin stimulus [IBA, ISS]
- endoplasmic reticulum tubular network organization [IMP]
- endosomal transport [IMP]
- establishment of neuroblast polarity [ISS]
- establishment of protein localization to endoplasmic reticulum membrane [IMP]
- establishment of protein localization to membrane [IMP]
- intracellular protein transport [IBA]
- membrane organization [TAS]
- polarized epithelial cell differentiation [ISS]
- protein localization to plasma membrane [IBA, ISS]
- protein secretion [IBA]
- regulation of exocytosis [IBA]
- vesicle docking involved in exocytosis [IBA]
- vesicle-mediated transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- cytoplasmic vesicle membrane [TAS]
- endoplasmic reticulum membrane [IDA]
- endoplasmic reticulum tubular network [IDA]
- endosome [IDA]
- endosome membrane [IBA]
- exocyst [ISS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- insulin-responsive compartment [IDA]
- plasma membrane [IDA]
- primary cilium [IDA]
- recycling endosome [IDA]
- trans-Golgi network [ISS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein.
Germline mutations in the Folliculin (FLCN) tumour suppressor gene result in fibrofolliculomas, lung cysts and renal cancers, but the precise mechanisms of tumour suppression by FLCN remain elusive. Here we identify Rab7A, a small GTPase important for endocytic trafficking, as a novel FLCN interacting protein and demonstrate that FLCN acts as a Rab7A GTPase-activating protein. FLCN-/- cells display slower trafficking ... [more]
Nat Commun Dec. 28, 2016; 8();15866 [Pubmed: 28656962]
Throughput
- Low Throughput
Curated By
- BioGRID