SMAD4
Gene Ontology Biological Process
- BMP signaling pathway [IDA, TAS]
- SMAD protein complex assembly [IDA]
- SMAD protein signal transduction [IDA]
- gene expression [TAS]
- intracellular signal transduction [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of protein catabolic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transcription, DNA-templated [IDA]
- palate development [ISS]
- positive regulation of BMP signaling pathway [IMP]
- positive regulation of SMAD protein import into nucleus [ISS]
- positive regulation of epithelial to mesenchymal transition [ISS]
- positive regulation of pathway-restricted SMAD protein phosphorylation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, TAS]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA]
- regulation of transforming growth factor beta receptor signaling pathway [IMP]
- regulation of transforming growth factor beta2 production [IMP]
- response to hypoxia [IMP]
- response to transforming growth factor beta [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [IDA, TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- I-SMAD binding [IPI]
- R-SMAD binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- core promoter proximal region sequence-specific DNA binding [IDA]
- identical protein binding [IPI]
- protein binding [IPI]
- protein binding transcription factor activity [IDA]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- transforming growth factor beta receptor, common-partner cytoplasmic mediator activity [IDA]
- DNA binding [IDA]
- I-SMAD binding [IPI]
- R-SMAD binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- core promoter proximal region sequence-specific DNA binding [IDA]
- identical protein binding [IPI]
- protein binding [IPI]
- protein binding transcription factor activity [IDA]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- transforming growth factor beta receptor, common-partner cytoplasmic mediator activity [IDA]
Gene Ontology Cellular Component
DVL1
Gene Ontology Biological Process
- Wnt signaling pathway, planar cell polarity pathway [IDA]
- canonical Wnt signaling pathway [IDA]
- dendrite morphogenesis [ISS]
- heart development [NAS]
- negative regulation of protein binding [IDA]
- negative regulation of protein kinase activity [IDA]
- neural tube development [IEP]
- neuromuscular junction development [ISS]
- neurotransmitter secretion [ISS]
- planar cell polarity pathway involved in neural tube closure [IBA]
- positive regulation of Wnt signaling pathway [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- protein localization to nucleus [IMP]
- receptor clustering [ISS]
- regulation of neurotransmitter levels [ISS]
- synapse organization [ISS]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Identification of three novel Smad binding proteins involved in cell polarity.
A yeast two-hybrid screen was utilized to identify novel Smad 3 binding proteins expressed in developing mouse orofacial tissue. Three proteins (Erbin, Par-3, and Dishevelled) were identified that share several similar structural and functional characteristics. Each contains at least one PDZ domain and all have been demonstrated to play a role in the establishment and maintenance of cell polarity. In ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID